MHC allele frequency distributions under parasite-driven selection: A simulation model
نویسندگان
چکیده
منابع مشابه
VNTR allele frequency distributions under the stepwise mutation model: a computer simulation approach.
Variable numbers of tandem repeats (VNTRs) are a class of highly informative and widely dispersed genetic markers. Despite their wide application in biological science, little is known about their mutational mechanisms or population dynamics. The objective of this work was to investigate four summary measures of VNTR allele frequency distributions: number of alleles, number of modes, range in a...
متن کاملRapid and adaptive evolution of MHC genes under parasite selection in experimental vertebrate populations
The genes of the major histocompatibility complex are the most polymorphic genes in vertebrates, with more than 1,000 alleles described in human populations. How this polymorphism is maintained, however, remains an evolutionary puzzle. Major histocompatibility complex genes have a crucial function in the adaptive immune system by presenting parasite-derived antigens to T lymphocytes. Because of...
متن کاملAllele frequency distribution under recurrent selective sweeps.
The allele frequency of a neutral variant in a population is pushed either upward or downward by directional selection on a linked beneficial mutation ("selective sweeps"). DNA sequences sampled after the fixation of the beneficial allele thus contain an excess of rare neutral alleles. This study investigates the allele frequency distribution under selective sweep models using analytic approxim...
متن کاملA Data-driven Method for Crowd Simulation using a Holonification Model
In this paper, we present a data-driven method for crowd simulation with holonification model. With this extra module, the accuracy of simulation will increase and it generates more realistic behaviors of agents. First, we show how to use the concept of holon in crowd simulation and how effective it is. For this reason, we use simple rules for holonification. Using real-world data, we model the...
متن کاملOptimization under frequency-dependent selection.
We consider a model of frequency-dependent selection, which we refer to as the Wildcard Model. A variety of more specific models, representing quite diverse biological situations, are covered by the Wildcard Model as particular cases. Two very different particular models that are subsumed by the Wildcard Model are the game theoretically motivated two-phenotype model of Lessard [Lessard, S.,1984...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMC Evolutionary Biology
سال: 2010
ISSN: 1471-2148
DOI: 10.1186/1471-2148-10-332